Using seaweed sugar to heal brain injuries

Brain

Dr Richard Williams from RMIT University and Associate Professor David Nisbet from The Australian National University have created a “hydrogel scaffold” that works in damaged brains.

Healthy cells exist in a scaffold that is mostly water with proteins forming a web, known as a hydrogel.

The breakthrough offers new hope for treating brain injuries and damaged tissue. While the brain can theoretically repair itself, it actually can’t as it seals a wound away to heal behind a scar, due, in part, to inflammation.

“Traumatic brain injury results in devastating long-term functional damage as the natural inflammatory response to injury prevents regrowth,” Williams said.

“This stops or prevents the healing process. So it’s critical that you find a natural way to stop the inflammation and scarring, yet encourage healing.”

That’s where Williams’ and Nisbet’s novel use of seaweed comes in.

Working with Tasmanian biopharmaceutical company, Marinova, the researchers combined a natural anti-inflammatory polysaccharide (sugar molecule) found in seaweed with short peptides (small proteins) to create the hydrogel scaffold that matches the structure of healthy brain tissue.

“We used fragments of these proteins to form an artificial hydrogel that the body recognises as healthy tissue. We then decorated this web with the sugars found in the seaweed to create the anti-inflammatory hydrogel system,” Williams said.

“The seaweed stops the scar and the scaffold lets the cells grow.

“The Japanese have long used seaweed for therapeutic purposes and it turns out there is an abundance of similar seaweed in Tasmania.”

The research team then injected the hydrogel scaffold into a damaged brain, with remarkable results.

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