An antibiotic used mostly to treat acne has been found to improve the quality of life for people with depression.
Researchers at Deakin University took a biological approach to treating major depression by adding a daily dose of minocycline – a broad-spectrum antibiotic that has been prescribed since 1971 – to the usual treatment of 71 people with the illness.
According to the results published in the Australian & New Zealand Journal of Psychiatry, patients taking minocycline reported improved functioning and quality of life.
There was also a trend towards a reduction in anxiety symptoms.
The trial support evidence that people with major depressive disorder have levels of inflammation in their body, says lead researcher Dr Olivia Dean.
“Minocycline reduces brain inflammation in cell models, and thus we wanted to see if it was useful for people,” said Dr Dean, from Deakin’s Centre for Innovation in Mental and Physical Health and Clinical Treatment.